MB21D2

Across TCGA pan-cancer cohorts, MB21D2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MB21D2 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MB21D2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MB21D2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

UCEC, KIRC, and ACC are the cancer types where MB21D2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.572	0.731	<.001	108	view →
KIRC	OS	Median	All	0.727	0.528	<.001	101	view →
ACC	DFS	Tertile	All	0.146	0.732	<.001	63	view →
LGG	DFS	Median	All	0.808	0.651	<.001	52	view →
COAD	DFS	Median	III,IV	0.578	0.747	.001	37	view →
HNSC	OS	Tertile	III,IV	0.294	0.562	.007	24	view →
STAD	OS	Median	III,IV	0.526	0.742	.015	23	view →
BLCA	DFS	Tertile	All	0.266	0.511	.004	16	view →
UCS	OS	Quartile	II,III,IV	0.708	0.238	.014	12	view →
CHOL	DFS	Quartile	All	0.780	0.116	.001	12	view →
LUAD	DFS	Quartile	IV	0.196	0.567	.043	12	view →
SCLC	OS	Tertile	II,III,IV	0.842	0.594	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MB21D2–UCEC (DFS)

Open the UCEC breakdown →