MB21D2

Across TCGA patient cohorts, MB21D2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MB21D2-associated genes across cancer lineages are FASN, p62 Lck ligand, and Cyclin-B1. Each is linked with MB21D2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MB21D2-to-partner and partner-to-MB21D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MB21D2-low versus MB21D2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MB21D2→partner) and Y-score (partner→MB21D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FASN →	+0.613	+2.816	.011	.036	3	3
UCEC	p62 Lck ligand →	+0.345	+2.502	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.574	+1.999	<.001	.002	3	2
UCEC	FoxM1 →	+0.172	+1.064	.029	.048	3	2
UCEC	JNK_pT183_Y185 →	-0.170	-1.934	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.089	+2.415	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

FASN by MB21D2 expression — LUSC

Explore this box plot interactively →