MB21D2

Across TCGA cell cohorts, MB21D2 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MB21D2-associated genes across cancer lineages are CPLX4, IAPP, and SLCO1C1. Each is linked with MB21D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MB21D2-to-partner and partner-to-MB21D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by MB21D2-low versus MB21D2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MB21D2→partner) and Y-score (partner→MB21D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.028	+3.807	<.001	.001	3	2
LARGE_INTESTINE	IAPP →	+0.337	+3.617	<.001	.004	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.518	+3.772	<.001	.003	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR1K1 →	+0.043	+3.069	.001	.005	3	1
LARGE_INTESTINE	PROKR1 →	+0.053	+4.047	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

CPLX4 by MB21D2 expression — LARGE_INTESTINE

Explore this box plot interactively →