MAZ

Across TCGA patient cohorts, MAZ mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAZ-associated genes across cancer lineages are ERK2, FoxM1, and Ku80. Each is linked with MAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both MAZ-to-partner and partner-to-MAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MAZ-low versus MAZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAZ→partner) and Y-score (partner→MAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.273	+3.169	.004	.018	3	1
UCEC	FoxM1 →	+0.448	+3.459	<.001	.005	3	1
UCEC	Ku80 →	+0.259	+2.335	.029	.020	3	1
UCEC	Notch1 →	+0.210	+3.459	.003	.005	3	1
UCEC	PCNA →	+0.294	+3.321	.006	.010	3	1
UCEC	STAT3_pY705 →	-0.494	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by MAZ expression — UCEC

Explore this box plot interactively →