MAX

Across TCGA pan-cancer cohorts, MAX mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MAX data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MAX mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAX expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where MAX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	IV	0.267	0.749	.038	6	view →
UCEC	DFS	Tertile	All	0.943	0.775	.037	2	view →
HNSC	OS	Median	II,III,IV	1.000	0.953	.019	2	view →
LUAD	DFS	Median	All	0.722	0.528	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MAX–PDAC (DFS)

Open the PDAC breakdown →