MAX

Across TCGA pan-cancer cohorts, MAX RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAX’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAX is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where MAX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.506	<.001	11	view →
LIHC	All	II,III,IV	+0.662	<.001	9	view →
KIRP	All	II,III,IV	+0.570	<.001	8	view →
UCEC	All	All	−0.746	<.001	6	view →
CHOL	All	All	+1.447	<.001	5	view →
BRCA	All	All	+0.196	<.001	4	view →
COAD	Female	All	−0.400	.010	2	view →
HNSC	All	All	+0.261	.018	2	view →
PRAD	All	All	−0.195	.001	2	view →
ESCA	All	All	+0.717	.009	1	view →
KICH	All	All	−0.270	.038	1	view →
LUSC	All	All	+0.140	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAX–KIRC

Open the KIRC breakdown →