MAX

Across TCGA patient cohorts, MAX mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAX-associated genes across cancer lineages are eEF2, ERK2, and GATA6. Each is linked with MAX in more than 1 cancer types. Because this analysis shows association rather than direction, both MAX-to-partner and partner-to-MAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MAX-low versus MAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAX→partner) and Y-score (partner→MAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.278	+2.459	.018	.018	3	1
UCEC	ERK2 →	+0.179	+2.087	.004	.005	3	1
UCEC	GATA6 →	-0.124	-3.444	.016	.004	3	1
UCEC	JNK2 →	+0.254	+2.263	<.001	<.001	3	1
UCEC	Ku80 →	+0.201	+2.179	.009	.001	3	1
UCEC	MEK1 →	+0.268	+1.847	.026	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by MAX expression — UCEC

Explore this box plot interactively →