MAVS

Across TCGA patient cohorts, MAVS protein abundance is significantly associated with the RNA expression of many other genes, with 15,328 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAVS-associated genes across cancer lineages are SLX4IP, FASTKD5, and TMEM230. Each is linked with MAVS in more than 6 cancer types. Because this analysis shows association rather than direction, both MAVS-to-partner and partner-to-MAVS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAVS versus SLX4IP in LSCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAVS→partner) and Y-score (partner→MAVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLX4IP →	+0.618	+0.327	<.001	<.001	3	7
LSCC	FASTKD5 →	+0.664	+0.296	<.001	<.001	3	7
COAD	TMEM230 →	+0.581	+0.315	<.001	<.001	3	7
COAD	MKKS →	+0.686	+0.362	<.001	<.001	3	7
LSCC	ATRN →	+0.774	+0.320	<.001	<.001	3	6
COAD	PSMF1 →	+0.515	+0.257	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,328 associations by consensus.

MAVS vs SLX4IP — LSCC

Explore this scatter interactively →