MAVS

Across TCGA pan-cancer cohorts, MAVS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAVS’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MAVS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAVS is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

LIHC, STAD, and BRCA are the cancer types where MAVS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAVS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.780	<.001	9	view →
STAD	All	II,III,IV	+0.826	<.001	6	view →
BRCA	Female	All	−0.363	<.001	6	view →
CHOL	Female	All	+2.696	<.001	5	view →
COAD	All	II,III,IV	−0.375	.002	4	view →
KIRP	Female	II,III,IV	+0.688	.008	3	view →
HNSC	All	III,IV	+0.442	.013	3	view →
THCA	All	All	−0.233	.007	3	view →
BLCA	Male	III,IV	−0.528	.008	2	view →
PRAD	All	All	+0.358	<.001	2	view →
LUAD	All	All	−0.262	.019	2	view →
LUSC	All	All	+0.252	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAVS–LIHC

Open the LIHC breakdown →