MAVS

Across TCGA patient cohorts, MAVS mutation is significantly associated with the RNA expression of many other genes, with 622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAVS-associated genes across cancer lineages are OR10Q2P, UCHL1-AS1, and RNU6-662P. Each is linked with MAVS in more than 1 cancer types. Because this analysis shows association rather than direction, both MAVS-to-partner and partner-to-MAVS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Q2P grouped by MAVS-low versus MAVS-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAVS→partner) and Y-score (partner→MAVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	OR10Q2P →	+0.049	+6.902	<.001	<.001	3	2
BRCA	UCHL1-AS1 →	+0.142	+4.189	<.001	.004	3	2
BLCA	RNU6-662P →	+0.300	+5.017	.001	.002	3	2
BLCA	TRAJ43 →	+0.379	+4.588	.008	.008	3	2
SKCM	DHDDS →	+0.487	+3.468	.003	.002	3	2
SKCM	VPS53 →	+0.626	+3.604	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 622 associations by consensus.

OR10Q2P by MAVS expression — LIHC

Explore this box plot interactively →