MAVS

Across TCGA cell cohorts, MAVS mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAVS-associated genes across cancer lineages are PIRT, MAGEB4, and CRISP1. Each is linked with MAVS in more than 1 cancer types. Because this analysis shows association rather than direction, both MAVS-to-partner and partner-to-MAVS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIRT grouped by MAVS-low versus MAVS-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAVS→partner) and Y-score (partner→MAVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PIRT →	+0.075	+4.169	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CRISP1 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PIRT by MAVS expression — STOMACH

Explore this box plot interactively →