MATN4

Across TCGA cell cohorts, MATN4 mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MATN4-associated genes across cancer lineages are IL3, FAM149A, and SNPH. Each is linked with MATN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MATN4-to-partner and partner-to-MATN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by MATN4-low versus MATN4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN4→partner) and Y-score (partner→MATN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IL3 →	+0.020	+4.807	<.001	.006	3	2
LARGE_INTESTINE	FAM149A →	+1.528	+3.212	<.001	.006	3	2
BLOOD_Leukemia	SNPH →	+0.502	+3.411	.005	.003	3	2
BLOOD_Lymphoma	KRT71 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.162	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

IL3 by MATN4 expression — BLOOD_Myeloma

Explore this box plot interactively →