MAT2B

Across TCGA patient cohorts, MAT2B mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAT2B-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and FoxM1. Each is linked with MAT2B in more than 2 cancer types. Because this analysis shows association rather than direction, both MAT2B-to-partner and partner-to-MAT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAT2B-low versus MAT2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT2B→partner) and Y-score (partner→MAT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.553	+1.827	.011	.015	3	3
UCEC	eIF4E →	+0.195	+2.247	.011	.001	3	2
UCEC	FoxM1 →	+0.237	+1.847	.012	.008	3	2
UCEC	MEK1 →	+0.512	+2.736	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.102	-2.000	.021	.029	3	2
UCEC	TFRC →	+0.496	+3.321	.011	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by MAT2B expression — UCEC

Explore this box plot interactively →