MAT2B

Across TCGA pan-cancer cohorts, MAT2B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MAT2B data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAT2B RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAT2B expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and READ are the cancer types where MAT2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.746	0.523	<.001	139	view →
MESO	OS	Tertile	All	0.620	0.283	<.001	108	view →
READ	OS	Median	II,III,IV	0.852	0.464	.001	61	view →
PAAD	OS	Median	All	0.500	0.759	<.001	47	view →
BLCA	DFS	Median	III,IV	0.347	0.212	.006	45	view →
HNSC	OS	Median	All	0.224	0.567	<.001	41	view →
SKCM	OS	Quartile	All	0.383	0.246	<.001	32	view →
COAD	OS	Median	II,III,IV	0.928	0.790	.010	23	view →
ESCA	DFS	Median	All	0.445	0.608	.014	22	view →
UCS	DFS	Tertile	II,III,IV	0.149	0.416	.033	12	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.177	.010	12	view →
PRAD	DFS	Tertile	All	0.907	0.748	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MAT2B–KIRC (OS)

Open the KIRC breakdown →