MAT2B

Across TCGA cell cohorts, MAT2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,996 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAT2B-associated GO terms across cancer lineages are S-adenosylmethionine biosynthetic process, Regulation of chromosome organization, and Regulation of chromosome segregation. Each is linked with MAT2B in more than 15 cancer types. Because this analysis shows association rather than direction, both MAT2B-to-partner and partner-to-MAT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S-adenosylmethionine biosynthetic process grouped by MAT2B-low versus MAT2B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT2B→partner) and Y-score (partner→MAT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	S-adenosylmethionine biosynthetic process →	+0.165	+1.320	<.001	<.001	3	16
BLOOD_Lymphoma	Regulation of chromosome organization →	+0.059	+0.818	<.001	.001	3	9
BREAST	Regulation of chromosome segregation →	+0.079	+0.586	.008	.005	3	9
LIVER	Negative regulation of protein modification by small protein conjugation or removal →	+0.082	+1.258	<.001	<.001	3	9
CNS	Alternative mRNA splicing, via spliceosome →	+0.110	+0.654	<.001	<.001	3	8
LIVER	Negative regulation of post-translational protein modification →	+0.071	+0.739	<.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

S-adenosylmethionine biosynthetic process by MAT2B expression — LUNG_SCLC

Explore this box plot interactively →