MAT2A

Across TCGA patient cohorts, MAT2A protein abundance is significantly associated with the RNA expression of many other genes, with 12,279 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAT2A-associated genes across cancer lineages are MRPL22, ITGA5, and IL1R1. Each is linked with MAT2A in more than 5 cancer types. Because this analysis shows association rather than direction, both MAT2A-to-partner and partner-to-MAT2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAT2A versus MRPL22 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT2A→partner) and Y-score (partner→MAT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MRPL22 →	+0.667	+0.245	<.001	<.001	3	6
LSCC	ITGA5 →	-0.651	-0.150	.002	.001	3	6
BRCA	IL1R1 →	-0.846	-0.198	.004	.003	3	5
BRCA	MFAP2 →	-0.947	-0.181	<.001	.001	3	5
CCRCC	MMP19 →	-1.393	-0.319	<.001	<.001	3	5
LSCC	LOXL1 →	-1.059	-0.212	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,279 associations by consensus.

MAT2A vs MRPL22 — OV

Explore this scatter interactively →