MAT2A

Across TCGA pan-cancer cohorts, MAT2A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MAT2A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MAT2A RNA is repressed in tumor relative to normal tissue. In most cancer types MAT2A is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and KICH are the cancer types where MAT2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAT2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−1.177	<.001	10	view →
BLCA	All	All	−1.048	<.001	10	view →
KICH	Female	II,III,IV	−2.052	<.001	8	view →
COAD	Female	All	+0.605	<.001	6	view →
KIRP	All	All	−0.554	<.001	4	view →
LUSC	All	All	−0.322	.007	4	view →
LIHC	Female	All	+0.644	.005	3	view →
CHOL	All	All	+1.777	<.001	2	view →
READ	All	III,IV	+1.024	.031	2	view →
PAAD	All	All	+0.389	.019	2	view →
STAD	Male	II,III,IV	+0.629	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MAT2A–THCA

Open the THCA breakdown →