MAT2A

Across TCGA patient cohorts, MAT2A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAT2A-associated genes across cancer lineages are RAD51, ASNS, and Cyclin-D1. Each is linked with MAT2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MAT2A-to-partner and partner-to-MAT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by MAT2A-low versus MAT2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT2A→partner) and Y-score (partner→MAT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.126	+2.321	.021	.033	3	2
UCEC	ASNS →	+0.463	+2.459	.001	.018	3	2
UCEC	Cyclin-D1 →	+0.194	+1.874	.002	.049	3	2
UCEC	eEF2 →	+0.384	+3.459	.006	.005	3	1
UCEC	eIF4E →	+0.163	+2.459	.049	.019	3	1
UCEC	ERK2 →	+0.176	+1.584	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RAD51 by MAT2A expression — UCEC

Explore this box plot interactively →