MAT2A

Across TCGA cell cohorts, MAT2A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,893 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MAT2A-associated GO terms across cancer lineages are Telomere organization, Transcription initiation at RNA polymerase I promoter, and Replication fork processing. Each is linked with MAT2A in more than 16 cancer types. Because this analysis shows association rather than direction, both MAT2A-to-partner and partner-to-MAT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere organization grouped by MAT2A-low versus MAT2A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT2A→partner) and Y-score (partner→MAT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Telomere organization →	+0.090	+0.907	.003	.002	3	17
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.127	+1.092	<.001	<.001	3	16
BONE	Replication fork processing →	+0.142	+1.075	.003	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Telomere maintenance →	+0.088	+1.512	<.001	<.001	3	16
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.124	+0.993	<.001	<.001	3	15
SOFT_TISSUE	DNA-templated DNA replication →	+0.122	+1.071	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,893 associations by consensus.

Telomere organization by MAT2A expression — BONE

Explore this box plot interactively →