MASTL

Across TCGA patient cohorts, MASTL protein abundance is significantly associated with the protein abundance of many other proteins, with 18,254 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MASTL-associated proteins across cancer lineages are ATAD2, ATAD2_S342, and AURKA. Each is linked with MASTL in more than 6 cancer types. Because this analysis shows association rather than direction, both MASTL-to-partner and partner-to-MASTL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MASTL versus ATAD2 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MASTL→partner) and Y-score (partner→MASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATAD2 →	+0.516	+0.474	<.001	<.001	3	6
LUAD	ATAD2_S342 →	+1.465	+0.491	<.001	<.001	3	6
LUAD	AURKA →	+1.050	+0.743	<.001	<.001	3	6
LUAD	AURKB →	+0.738	+0.495	<.001	<.001	3	6
UCEC	BUB1B_S543 →	+1.092	+0.816	<.001	<.001	3	6
LUAD	CDC20_T70 →	+1.106	+0.656	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,254 associations by consensus.

MASTL vs ATAD2 — BRCA

Explore this scatter interactively →