MASTL

Across TCGA pan-cancer cohorts, MASTL RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MASTL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MASTL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MASTL is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where MASTL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MASTL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.326	<.001	12	view →
BLCA	Male	All	+1.335	<.001	11	view →
LUAD	Male	III,IV	+1.183	<.001	11	view →
KIRC	All	IV	+0.583	<.001	11	view →
COAD	Male	IV	+1.228	<.001	10	view →
STAD	All	III,IV	+1.553	<.001	9	view →
LIHC	Female	II,III,IV	+1.124	<.001	9	view →
LUSC	Male	II,III,IV	+1.521	<.001	8	view →
KIRP	All	II,III,IV	+0.593	.005	7	view →
THCA	All	All	−0.349	<.001	7	view →
UCEC	All	III,IV	+1.334	<.001	6	view →
KICH	Female	All	−1.168	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MASTL–HNSC

Open the HNSC breakdown →