MASTL

Across TCGA patient cohorts, MASTL mutation is significantly associated with the RNA expression of many other genes, with 1,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MASTL-associated genes across cancer lineages are PHKG1P1, RBAK-RBAKDN, and RNA5SP412. Each is linked with MASTL in more than 1 cancer types. Because this analysis shows association rather than direction, both MASTL-to-partner and partner-to-MASTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHKG1P1 grouped by MASTL-low versus MASTL-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASTL→partner) and Y-score (partner→MASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PHKG1P1 →	+0.041	+4.559	<.001	.006	3	2
UCEC	RBAK-RBAKDN →	+0.076	+1.498	<.001	.003	3	2
UCEC	RNA5SP412 →	+0.564	+2.028	<.001	<.001	3	2
UCEC	PRF1 →	+0.678	+2.008	.003	.001	3	2
UCEC	SAMD11 →	-0.877	-2.383	.001	.003	3	2
UCEC	MIR34AHG →	+0.290	+2.010	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,668 associations by consensus.

PHKG1P1 by MASTL expression — CESC

Explore this box plot interactively →