MASTL

Across TCGA patient cohorts, MASTL mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MASTL-associated genes across cancer lineages are Notch1, STAT3_pY705, and 4E-BP1. Each is linked with MASTL in more than 1 cancer types. Because this analysis shows association rather than direction, both MASTL-to-partner and partner-to-MASTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MASTL-low versus MASTL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASTL→partner) and Y-score (partner→MASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.121	+1.137	.006	.041	3	2
UCEC	STAT3_pY705 →	-0.376	-1.990	<.001	.002	3	2
UCEC	4E-BP1 →	+0.232	+2.584	.006	.010	3	2
UCEC	14-3-3_beta →	-0.071	-1.673	.024	.040	3	1
UCEC	eIF4E →	+0.152	+2.115	.022	<.001	3	1
UCEC	eIF4G →	+0.293	+2.321	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by MASTL expression — UCEC

Explore this box plot interactively →