MASTL

Across TCGA cell cohorts, MASTL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,617 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MASTL-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Regulation of mitotic metaphase/anaphase transition, and Regulation of nuclear division. Each is linked with MASTL in more than 17 cancer types. Because this analysis shows association rather than direction, both MASTL-to-partner and partner-to-MASTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by MASTL-low versus MASTL-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MASTL→partner) and Y-score (partner→MASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of metaphase/anaphase transition of cell cycle →	+0.136	+1.152	<.001	<.001	3	18
PANCREAS	Regulation of mitotic metaphase/anaphase transition →	+0.116	+1.048	<.001	<.001	3	18
BREAST	Regulation of nuclear division →	+0.122	+1.117	<.001	<.001	3	18
PANCREAS	Regulation of chromosome segregation →	+0.111	+1.069	<.001	<.001	3	18
BREAST	Regulation of mitotic nuclear division →	+0.127	+1.117	<.001	<.001	3	18
PANCREAS	Regulation of mitotic sister chromatid separation →	+0.155	+1.120	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,617 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by MASTL expression — BREAST

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