MASTL

Across TCGA cell cohorts, MASTL mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MASTL-associated genes across cancer lineages are KRTAP5-3, SNPH, and OR1L4. Each is linked with MASTL in more than 1 cancer types. Because this analysis shows association rather than direction, both MASTL-to-partner and partner-to-MASTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-3 grouped by MASTL-low versus MASTL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASTL→partner) and Y-score (partner→MASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP5-3 →	+0.024	+4.507	<.001	.001	3	1
LARGE_INTESTINE	SNPH →	+0.802	+3.215	.006	.009	3	1
LARGE_INTESTINE	OR1L4 →	+0.023	+2.977	<.001	.006	3	1
LARGE_INTESTINE	DRD3 →	+0.007	+2.977	<.001	.006	3	1
LARGE_INTESTINE	TMEM132C →	+0.439	+2.560	<.001	.008	3	1
LARGE_INTESTINE	TIFAB →	+0.003	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

KRTAP5-3 by MASTL expression — BLOOD_Leukemia

Explore this box plot interactively →