MAST4-AS1

Across TCGA pan-cancer cohorts, MAST4-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MAST4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAST4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MAST4-AS1 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where MAST4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAST4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	−1.383	<.001	11	view →
KIRC	All	II,III,IV	−0.514	<.001	11	view →
KICH	Male	All	−0.900	<.001	7	view →
BRCA	All	II,III,IV	−0.404	<.001	6	view →
READ	All	All	−0.743	.005	4	view →
CHOL	Male	All	+1.211	<.001	3	view →
BLCA	Male	All	−0.663	.010	3	view →
LUAD	Male	All	+0.541	.007	3	view →
COAD	All	All	−0.287	.009	3	view →
LIHC	All	All	+0.176	<.001	3	view →
STAD	All	II,III,IV	−0.460	.027	2	view →
THCA	Male	All	−0.379	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MAST4-AS1–HNSC

Open the HNSC breakdown →