MASP2

Across TCGA cell cohorts, MASP2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MASP2-associated genes across cancer lineages are OR2A14, IFNA13, and OR8B2. Each is linked with MASP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MASP2-to-partner and partner-to-MASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A14 grouped by MASP2-low versus MASP2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP2→partner) and Y-score (partner→MASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2A14 →	+0.022	+5.643	.002	.002	3	1
BLOOD_Lymphoma	IFNA13 →	+0.160	+4.867	<.001	.009	3	1
LUNG_SCLC	OR8B2 →	+0.055	+5.029	<.001	.006	3	1
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1
BLOOD_Leukemia	NXPE4 →	+0.027	+4.276	<.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2A14 by MASP2 expression — BLOOD_Lymphoma

Explore this box plot interactively →