MASP1

Across TCGA cell cohorts, MASP1 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MASP1-associated genes across cancer lineages are FOXR1, DPRX, and IFNA14. Each is linked with MASP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MASP1-to-partner and partner-to-MASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXR1 grouped by MASP1-low versus MASP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP1→partner) and Y-score (partner→MASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FOXR1 →	+0.132	+4.222	<.001	.007	3	1
SOFT_TISSUE	DPRX →	+0.049	+4.369	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR7E24 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.024	+4.369	<.001	.008	3	1
CNS	AKR1D1 →	+0.055	+4.169	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

FOXR1 by MASP1 expression — SOFT_TISSUE

Explore this box plot interactively →