Across TCGA patient cohorts, MAS1L mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAS1L-associated genes across cancer lineages are Notch1, ASNS, and Caspase-8. Each is linked with MAS1L in more than 2 cancer types. Because this analysis shows association rather than direction, both MAS1L-to-partner and partner-to-MAS1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAS1L→partner) and Y-score (partner→MAS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.159	+1.887	.003	.029	3	3
UCEC	ASNS →	+0.469	+2.321	<.001	.005	3	2
UCEC	Caspase-8 →	-0.238	-2.780	.013	.003	3	2
UCEC	EGFR →	-0.138	-1.700	.024	.042	3	1
UCEC	eIF4E →	+0.196	+2.087	.015	.005	2	2
UCEC	FoxM1 →	+0.256	+2.584	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

MAS1L survival (RNA) · tumor vs normal (RNA) · all MAS1L data types