Across TCGA pan-cancer cohorts, MAS1L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MAS1L’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where MAS1L RNA is repressed in tumor relative to normal tissue. In most cancer types MAS1L is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.
COAD, BLCA, and LUSC are the cancer types where MAS1L tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAS1L RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.