MARVELD2

Across TCGA patient cohorts, MARVELD2 mutation is significantly associated with the RNA expression of many other genes, with 882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARVELD2-associated genes across cancer lineages are FOXO1B, ATP6V0D1, and MED27. Each is linked with MARVELD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARVELD2-to-partner and partner-to-MARVELD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO1B grouped by MARVELD2-low versus MARVELD2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARVELD2→partner) and Y-score (partner→MARVELD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	FOXO1B →	+0.146	+5.039	<.001	.008	3	2
UCEC	ATP6V0D1 →	+0.631	+2.818	.004	.001	3	2
UCEC	MED27 →	+0.418	+3.406	.004	.004	3	2
UCEC	BAP1 →	+0.380	+3.467	.004	.002	3	2
UCEC	PITX2 →	+1.042	+3.201	<.001	.009	3	2
UCEC	ENTR1 →	+0.498	+3.475	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 882 associations by consensus.

FOXO1B by MARVELD2 expression — READ

Explore this box plot interactively →