MARVELD2

Across TCGA pan-cancer cohorts, MARVELD2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MARVELD2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MARVELD2 RNA is repressed in tumor relative to normal tissue. In most cancer types MARVELD2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BLCA are the cancer types where MARVELD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MARVELD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−2.357	<.001	12	view →
THCA	Male	III,IV	−1.151	<.001	10	view →
BLCA	All	III,IV	+1.654	.004	8	view →
KICH	Male	All	−1.800	<.001	7	view →
UCEC	All	All	+1.646	<.001	6	view →
BRCA	All	III,IV	+1.458	<.001	6	view →
STAD	All	All	+1.096	<.001	5	view →
CHOL	All	All	+1.344	<.001	3	view →
KIRP	All	All	−0.841	<.001	3	view →
LIHC	All	All	+0.698	<.001	3	view →
LUSC	All	All	−0.341	.002	3	view →
PRAD	All	All	+0.577	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MARVELD2–KIRC

Open the KIRC breakdown →