MARS2

Across TCGA cell cohorts, MARS2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARS2-associated genes across cancer lineages are KHDC3L, OR9I1, and C1orf141. Each is linked with MARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARS2-to-partner and partner-to-MARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by MARS2-low versus MARS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARS2→partner) and Y-score (partner→MARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.205	+3.607	<.001	.004	3	2
SKIN	OR9I1 →	+0.005	+5.022	<.001	.002	3	1
CNS	C1orf141 →	+0.012	+5.321	<.001	.005	3	1
BLOOD_Leukemia	SLC32A1 →	+0.525	+3.223	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.013	+3.365	.006	.005	3	1
BLOOD_Leukemia	MUC5B →	+0.362	+3.474	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

KHDC3L by MARS2 expression — BLOOD_Leukemia

Explore this box plot interactively →