MARS1

Across TCGA cell cohorts, MARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,618 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MARS1-associated GO terms across cancer lineages are Negative regulation of translation in response to endoplasmic reticulum stress, tRNA transport, and Formate biosynthetic process. Each is linked with MARS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both MARS1-to-partner and partner-to-MARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translation in response to endoplasmic reticulum stress grouped by MARS1-low versus MARS1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARS1→partner) and Y-score (partner→MARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.201	+0.883	<.001	<.001	3	12
LIVER	tRNA transport →	+0.145	+1.003	<.001	<.001	3	12
LARGE_INTESTINE	Formate biosynthetic process →	+0.130	+0.683	<.001	<.001	2	12
CNS	L-glutamine import across plasma membrane →	+0.151	+0.740	<.001	.003	3	9
BLOOD_Leukemia	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.106	+1.000	<.001	<.001	3	9
LIVER	HRI-mediated signaling →	+0.132	+0.860	.003	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,618 associations by consensus.

Negative regulation of translation in response to endoplasmic reticulum stress by MARS1 expression — BLOOD_Myeloma

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