MARS1

Across TCGA pan-cancer cohorts, MARS1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MARS1 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MARS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MARS1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

KIRC, MESO, and SCLC are the cancer types where MARS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	III,IV	0.563	0.714	.001	141	view →
MESO	OS	Median	All	0.382	0.706	<.001	117	view →
SCLC	OS	Quartile	All	0.782	0.336	<.001	102	view →
ACC	DFS	Median	All	0.409	0.750	<.001	87	view →
KICH	DFS	Quartile	All	0.494	1.000	<.001	85	view →
LIHC	OS	Median	All	0.609	0.760	<.001	80	view →
UVM	DFS	Tertile	III,IV	0.246	0.925	<.001	69	view →
BRCA	OS	Tertile	II,III,IV	0.548	0.646	<.001	54	view →
BLCA	DFS	Quartile	All	0.298	0.713	.002	47	view →
LGG	DFS	Tertile	All	0.740	0.872	<.001	38	view →
HNSC	OS	Median	All	0.612	0.801	<.001	28	view →
LUSC	DFS	Tertile	III,IV	0.143	0.897	<.001	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MARS1–KIRC (DFS)

Open the KIRC breakdown →