MARK4

Across TCGA patient cohorts, MARK4 mutation is significantly associated with the RNA expression of many other genes, with 3,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARK4-associated genes across cancer lineages are MIR4667, RN7SKP245, and H3Y2. Each is linked with MARK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MARK4-to-partner and partner-to-MARK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4667 grouped by MARK4-low versus MARK4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARK4→partner) and Y-score (partner→MARK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4667 →	+0.124	+3.095	.002	.007	3	3
HNSC	RN7SKP245 →	+0.063	+4.146	<.001	.008	3	3
UCEC	H3Y2 →	+0.417	+2.241	<.001	<.001	3	3
COAD	MTCO2P23 →	+0.164	+4.136	<.001	<.001	3	3
COAD	NCOR1P2 →	+0.104	+4.087	.002	.006	3	3
UCEC	OPA3 →	+0.320	+2.124	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,193 associations by consensus.

MIR4667 by MARK4 expression — SKCM

Explore this box plot interactively →