MARK2P5

Across TCGA pan-cancer cohorts, MARK2P5 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated MARK2P5 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MARK2P5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MARK2P5 expression acts as an unfavorable survival marker, although some lineages such as KIRP show a favorable association.

SKCM, KIRC, and READ are the cancer types where MARK2P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.142	0.351	<.001	72	view →
KIRC	DFS	Tertile	IV	0.162	0.380	.005	48	view →
READ	DFS	Tertile	All	0.269	0.819	.009	45	view →
LUSC	DFS	Tertile	II,III,IV	0.174	0.614	.002	45	view →
LIHC	OS	Tertile	III,IV	0.370	0.759	<.001	45	view →
LGG	OS	Tertile	All	0.361	0.574	<.001	31	view →
THCA	DFS	Tertile	II,III,IV	0.744	0.937	.004	18	view →
PCPG	DFS	Tertile	All	0.070	0.936	<.001	9	view →
THYM	DFS	Tertile	All	0.671	0.919	.040	3	view →
KIRP	DFS	Tertile	All	0.982	0.896	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

MARK2P5–SKCM (OS)

Open the SKCM breakdown →