MARK2P5

Across TCGA pan-cancer cohorts, MARK2P5 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MARK2P5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MARK2P5 RNA is repressed in tumor relative to normal tissue. In most cancer types MARK2P5 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and THCA are the cancer types where MARK2P5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MARK2P5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	−0.113	.002	6	view →
KIRC	Male	All	−0.039	<.001	5	view →
THCA	Female	All	−0.084	.002	4	view →
KICH	Male	All	−0.050	.009	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MARK2P5–KIRP

Open the KIRP breakdown →