MARCKSL1

Across TCGA cell cohorts, MARCKSL1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MARCKSL1-associated genes across cancer lineages are IZUMO1R, FABP9, and GPR101. Each is linked with MARCKSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCKSL1-to-partner and partner-to-MARCKSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO1R grouped by MARCKSL1-low versus MARCKSL1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCKSL1→partner) and Y-score (partner→MARCKSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FABP9 →	+0.060	+5.357	<.001	.003	3	1
BLOOD_Leukemia	GPR101 →	+0.167	+4.551	<.001	.004	3	1
BLOOD_Leukemia	NKX2-6 →	+0.507	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	NPAP1 →	+0.075	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PRR30 →	+0.024	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IZUMO1R by MARCKSL1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →