MARCKS

Across TCGA pan-cancer cohorts, MARCKS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MARCKS data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MARCKS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MARCKS expression acts as an unfavorable survival marker.

PDAC, CCRCC, and UCEC are the cancer types where MARCKS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.254	0.491	.001	24	view →
CCRCC	DFS	Quartile	All	0.841	0.967	.021	10	view →
UCEC	OS	Median	All	0.853	0.967	.025	4	view →
HNSC	DFS	Tertile	IV	0.589	0.832	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MARCKS–PDAC (OS)

Open the PDAC breakdown →