MARCKS

Across TCGA pan-cancer cohorts, MARCKS RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MARCKS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MARCKS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MARCKS is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where MARCKS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MARCKS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.439	<.001	12	view →
HNSC	All	IV	+0.959	<.001	12	view →
COAD	Female	All	−1.670	<.001	11	view →
KIRP	All	II,III,IV	+1.460	<.001	9	view →
LIHC	Female	II,III,IV	+1.734	<.001	8	view →
LUSC	Female	All	+1.263	<.001	8	view →
KICH	Female	All	−1.408	<.001	7	view →
READ	All	All	−1.156	<.001	7	view →
BLCA	All	All	+0.806	.001	7	view →
LUAD	All	All	+0.545	<.001	5	view →
CHOL	Male	All	+2.768	<.001	3	view →
UCEC	All	IV	−1.205	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MARCKS–KIRC

Open the KIRC breakdown →