MARCKS

Across TCGA patient cohorts, MARCKS mutation is significantly associated with the RNA expression of many other genes, with 956 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCKS-associated genes across cancer lineages are RNU1-1, RBM12B-AS1, and RASSF1-AS1. Each is linked with MARCKS in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCKS-to-partner and partner-to-MARCKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-1 grouped by MARCKS-low versus MARCKS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCKS→partner) and Y-score (partner→MARCKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-1 →	+0.207	+2.631	.005	.007	3	2
UCEC	RBM12B-AS1 →	+0.577	+3.361	.003	.005	3	1
UCEC	RASSF1-AS1 →	+0.747	+3.213	<.001	.009	3	1
BLCA	PFN1P10 →	+0.168	+5.038	<.001	.009	3	1
UCEC	TOP3B →	+0.160	+3.421	.001	.006	3	1
UCEC	ACO2 →	+0.780	+3.201	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 956 associations by consensus.

RNU1-1 by MARCKS expression — UCEC

Explore this box plot interactively →