MARCKS

Across TCGA cell cohorts, MARCKS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,957 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MARCKS-associated GO terms across cancer lineages are Regulation of actin filament organization, Actin filament organization, and Blood coagulation, fibrin clot formation. Each is linked with MARCKS in more than 9 cancer types. Because this analysis shows association rather than direction, both MARCKS-to-partner and partner-to-MARCKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of actin filament organization grouped by MARCKS-low versus MARCKS-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCKS→partner) and Y-score (partner→MARCKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of actin filament organization →	+0.061	+1.836	.002	.002	3	10
LARGE_INTESTINE	Actin filament organization →	+0.067	+1.062	<.001	<.001	3	9
PANCREAS	Blood coagulation, fibrin clot formation →	+0.293	+1.022	<.001	.008	3	9
OESOPHAGUS	Regulation of extrinsic apoptotic signaling pathway →	+0.081	+0.832	<.001	.004	2	10
CNS	Wound healing →	+0.079	+0.929	<.001	<.001	3	9
LIVER	Regulation of angiogenesis →	+0.077	+1.209	.004	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,957 associations by consensus.

Regulation of actin filament organization by MARCKS expression — STOMACH

Explore this box plot interactively →