Across TCGA patient cohorts, MARCHF11 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCHF11-associated genes across cancer lineages are FoxM1, p27_pT157, and MIG-6. Each is linked with MARCHF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF11-to-partner and partner-to-MARCHF11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF11→partner) and Y-score (partner→MARCHF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.308	+2.999	.008	.035	3	2
SKCM	p27_pT157 →	+0.274	+3.584	<.001	.002	3	2
UCEC	MIG-6 →	+0.112	+2.013	.012	.018	3	2
SKCM	Bax →	-0.273	-2.459	.013	.020	3	1
SKCM	c-Jun_pS73 →	+0.160	+3.033	.015	.017	3	1
SKCM	C-Raf_pS338 →	+0.177	+2.195	.003	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

MARCHF11 survival (RNA) · tumor vs normal (RNA) · all MARCHF11 data types