MARCHF11-AS1

Across TCGA pan-cancer cohorts, MARCHF11-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated MARCHF11-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher MARCHF11-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MARCHF11-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

CESC, LUAD, and UVM are the cancer types where MARCHF11-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.222	0.764	.002	108	view →
LUAD	OS	Tertile	II,III,IV	0.109	0.750	<.001	99	view →
UVM	OS	Tertile	All	0.317	0.938	<.001	72	view →
KICH	DFS	Tertile	All	0.369	0.922	<.001	54	view →
THCA	DFS	Tertile	IV	0.424	0.965	<.001	48	view →
STAD	DFS	Tertile	III,IV	0.393	0.634	.017	45	view →
SKCM	OS	Tertile	IV	0.337	0.775	.009	33	view →
UCEC	DFS	Tertile	All	0.669	0.847	<.001	30	view →
BLCA	DFS	Tertile	III,IV	0.105	0.575	<.001	27	view →
ESCA	OS	Tertile	III,IV	0.846	0.365	.028	24	view →
LAML	DFS	Tertile	All	0.176	0.597	.004	18	view →
LUSC	OS	Tertile	III,IV	0.086	0.664	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

MARCHF11-AS1–CESC (OS)

Open the CESC breakdown →