Across TCGA pan-cancer cohorts, MARCHF11-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MARCHF11-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where MARCHF11-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MARCHF11-AS1 is over-expressed in tumor.
PRAD and THCA are the cancer types where MARCHF11-AS1 tumor–normal differential expression is most reproducible.