MARCHF10-DT

Across TCGA pan-cancer cohorts, MARCHF10-DT RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MARCHF10-DT data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher MARCHF10-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MARCHF10-DT expression acts as an unfavorable survival marker, although some lineages such as ESCA and BLCA show a favorable association.

KICH, CESC, and GBM are the cancer types where MARCHF10-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.587	0.976	<.001	51	view →
CESC	OS	Quartile	IV	0.157	0.637	<.001	48	view →
GBM	OS	Quartile	All	0.233	0.455	<.001	36	view →
ACC	DFS	Tertile	All	0.218	0.765	<.001	27	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
KIRC	OS	Median	All	0.754	0.833	.001	23	view →
DLBC	DFS	Quartile	IV	0.145	0.785	.017	22	view →
ESCA	OS	Median	IV	0.698	0.222	.006	21	view →
TGCT	DFS	Tertile	All	0.693	0.878	.009	18	view →
LIHC	DFS	Tertile	III,IV	0.086	0.451	<.001	18	view →
PRAD	OS	Tertile	All	0.980	0.996	.003	18	view →
READ	OS	Tertile	III,IV	0.287	0.772	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MARCHF10-DT–KICH (OS)

Open the KICH breakdown →