MAPT-IT1

Across TCGA pan-cancer cohorts, MAPT-IT1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated MAPT-IT1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MAPT-IT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAPT-IT1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, UVM, and KIRC are the cancer types where MAPT-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.969	0.877	<.001	118	view →
UVM	DFS	Tertile	All	0.387	0.679	<.001	89	view →
KIRC	OS	Median	All	0.710	0.554	<.001	86	view →
UCEC	DFS	Tertile	All	0.819	0.910	.004	84	view →
COAD	DFS	Tertile	IV	0.216	0.541	<.001	63	view →
PCPG	DFS	Median	All	0.948	0.621	<.001	33	view →
LGG	OS	Tertile	All	0.598	0.417	<.001	28	view →
HNSC	OS	Tertile	II,III,IV	0.746	0.541	.020	21	view →
PAAD	DFS	Median	All	0.400	0.214	.019	13	view →
SARC	OS	Median	All	0.761	0.876	.007	12	view →
UCS	OS	Quartile	All	0.367	0.663	.015	10	view →
LUSC	OS	Quartile	All	0.841	0.753	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

MAPT-IT1–BRCA (OS)

Open the BRCA breakdown →