MAPT-IT1

Across TCGA pan-cancer cohorts, MAPT-IT1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MAPT-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAPT-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAPT-IT1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where MAPT-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPT-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.132	<.001	10	view →
COAD	All	II,III,IV	−0.030	<.001	10	view →
HNSC	All	All	−0.018	.004	8	view →
BRCA	All	All	+0.467	<.001	6	view →
LIHC	All	All	+0.077	.001	5	view →
STAD	All	All	−0.063	.001	3	view →
PRAD	All	All	−0.065	.004	2	view →
LUSC	Male	II,III,IV	+0.011	.011	2	view →
THCA	All	IV	−0.017	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MAPT-IT1–KIRC

Open the KIRC breakdown →