MAPT-AS1

Across TCGA pan-cancer cohorts, MAPT-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MAPT-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAPT-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAPT-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and LGG are the cancer types where MAPT-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.730	0.530	<.001	154	view →
BRCA	OS	Median	All	0.961	0.886	<.001	124	view →
LGG	OS	Median	All	0.881	0.736	<.001	49	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
TGCT	DFS	Tertile	II,III,IV	0.618	0.950	.025	36	view →
MESO	DFS	Quartile	II,III,IV	0.232	0.410	.007	30	view →
LAML	DFS	Tertile	All	0.731	0.492	.004	30	view →
BLCA	OS	Tertile	II,III,IV	0.860	0.692	.009	24	view →
UCEC	DFS	Tertile	All	0.753	0.848	.021	24	view →
UCS	OS	Tertile	III,IV	0.394	0.669	.042	18	view →
READ	DFS	Tertile	III,IV	0.059	0.761	<.001	18	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MAPT-AS1–KIRC (OS)

Open the KIRC breakdown →